Posts Tagged ‘obesity treatment’

High Hopes for a New Diabesity Drug

August 18, 2017 — Call us superstitious. The hopes for a new diabesity drug – semaglutide – are growing higher. And to us, that’s a good news, bad news story. The high hopes are coming from good clinical results for this new GLP-1 agonist in a head-to-head comparison with dulaglutide from Eli Lilly. Dulaglutide is a GLP-1 activator that’s already on […]

The Tangled Relationship Between Obesity and Depression

August 17, 2017 — Obesity and depression seem to travel together. This link is a tricky one and the nature of the relationship presents a real challenge for scientists to unravel. But one thing is sure. These two diseases are rising in parallel. An Unmistakable Rise in Severe Psychological Distress Look no further than the dramatic rise in deaths […]

Does Obesity Mess with Your Brain’s Reward Center?

August 14, 2017 — For several years now, neuroscientists have been looking for connections between obesity and how our brains process rewards. Dopamine receptors play a role in the reward you feel when you eat especially tasty foods. And prior research suggests people with obesity have fewer dopamine receptors. Now new research in Obesity shows that young adults with […]

Moving Ahead Despite Imperfect Information in Obesity

August 5, 2017 — Yesterday, we had the privilege to present to a few hundred diabetes educators at AADE17 in Indianapolis. The subject was bias and how it interferes with progress against childhood obesity. So we spent a good bit of time talking about the abundance of imperfect information about obesity. The best question of the day came from […]

When to Have Bariatric Surgery: Early or Late?

August 1, 2017 — You can find plenty of bad advice about obesity in general and bariatric surgery in specific. One bit that’s especially harmful is the false notion that bariatric surgery should be “a last resort.” But a new study in JAMA Surgery provides further clarity. Putting off surgery while obesity gets progressively worse will stack the odds […]

Better Sleep, Better Health, Less Obesity

July 30, 2017 — Seven to nine hours of sleep per night might significantly improve health and reduce obesity risk. A new study published in PLOS ONE finds that people who sleep only six hours per night have a waist that’s three centimeters bigger than people who get nine hours. With better sleep, the odds of diabetes drop as […]

Boon or Bane? The FDA Cardiovascular Safety Hurdle

July 29, 2017 — Almost ten years ago, FDA set a new hurdle for approving new diabetes drugs. Before one of these new drugs could be approved, the sponsoring company would need an expensive cardiovascular safety study. How expensive? The price tag might run as high as a billion dollars. FDA laid this same requirement on new obesity drugs, […]

Six Hard Questions to Ask About Obesity Cause and Effect

July 25, 2017 — Yesterday, Kevin Fontaine and David Allison opened their third conference on causality in obesity research at the UAB Nutrition and Obesity Research Center. They explained the growing urgency to ask hard questions about cause and effect in obesity. Targeting Elusive Causes for Obesity For three decades, obesity prevalence has been growing relentlessly. And yet, we […]

Sprinkling Bad Stats on Thin Data in Childhood Obesity

July 23, 2017 — Let’s face it. The evidence base for childhood obesity treatment is thin. We don’t need bad stats to muddy the waters even further. But a recent paper in Pediatrics does just that. The authors conducted a randomized controlled trial of metformin in 160 children with obesity. They enrolled equal numbers of male, female, prepubertal, and […]

Surgery, Suffering, and Money in Obesity and Diabetes

July 20, 2017 — Does gastric bypass surgery save money for patients with obesity and diabetes? That’s the question a new study answers in Obesity this week. Suffering with a chronic disease – at least in the short term – is usually free. So finding savings would indeed be surprising in a two-year study such as this one. This study holds […]