Archive for November, 2023

Inflated Claims and Inadequate Testing for Rexulti

November 20, 2023 — FDA has a bone to pick with Otsuka, the company that sells Rexulti (brexpiprazole). The agency is taking issue with false advertising by the company for this drug used in schizophrenia and severe depression. To us, this problem of inflated efficacy claims is especially noteworthy because, for people with obesity who may need this drug, […]

Human Diversity, Identity, and Disease

November 19, 2023 — “I am.” These two words define so many struggles we face in public discourse today. People define their own identities in diverse ways and fiercely defend them. Disparage a person’s identity and you are attacking them. What follows is not gentle, rational, or easily calmed. Right now, we see how potent it is in public […]

Do Cancer Drugs Work Safely for People with Obesity? Maybe

November 18, 2023 — At a time when nearly half of the U.S. population is living with obesity, this should be an easy question to answer. Obesity clearly causes some forms of cancer and as the prevalence of obesity is rising, patterns of cancer prevalence are shifting, too. So, yes, we should be able to say with great confidence […]

Health Systems Rigged to Interrupt Obesity Treatment

November 17, 2023 — It’s not easy. Getting access to good obesity care and maintaining it is a challenge that is especially frustrating as we see that the options for care are improving. But it seems that health systems right now are rigged to interrupt obesity treatment. An illustration of this comes from a recent study published in Obesity. […]

A Conversation with Dr. Ania Jastreboff About the SELECT Trial

November 16, 2023 — It was an amazing moment. Hundreds upon hundreds people packed into huge convention hall to hear about the detailed outcomes of the first ever randomized controlled trial to show that treating obesity could prevent heart attacks, strokes, and cardiovascular deaths. The implications of the SELECT trial for obesity care will be enormous and we had […]

Who Benefits from Pharmacy Benefit Managers?

November 15, 2023 — A trip into the world of pharmacy benefit managers (PBMs) is enough to make our heads spin. It leads us to wonder: exactly who benefits from pharmacy benefit managers? The answer is not clear, but it seems obvious that patients in need of affordable medicine do not. In Search of a Fair Deal The biggest […]

Cutting Salt “Works as Well” as Blood Pressure Medicines?

November 14, 2023 — Please. We don’t need fake controversies and false comparative claims. But in reporting on an excellent new study of the effects of cutting salt on blood pressure, we’re getting a little bit of both. The study that is generating this frenzy simply doesn’t line up with the headlines that reporters are spinning out of it. […]

The Fake Line Between Obesity and Other Metabolic Disease

November 13, 2023 — Nestled in the midst of a lot of good news last week was a nasty reminder of a persistent problem. It’s the fake line that people persist in drawing between obesity and other metabolic disease. Lilly did it (with consent from FDA) when they decided to put a different brand name on tirzepatide for obesity. […]

Three Details Worth Knowing About the SELECT Study

November 12, 2023 — For some time to come, we will be learning more and more about the details and implications of the landmark SELECT study published yesterday in NEJM and presented at the American Heart Association Scientific Sessions in Philadelphia. A massive crowd packed the meeting hall yesterday for good reason. These results will change the practice of […]

The SELECT Study Makes One Thing Undeniable

November 11, 2023 — Newly published in full, the results of the SELECT study of semaglutide for cardiovascular outcomes in persons with obesity but not diabetes makes one thing undeniable. Obesity is a chronic, treatable disease. Treating obesity requires more than just telling a person to change their lifestyle. It involves addressing the disease pathology that is at work, […]