
Consensus on Diagnosing Obesity in an Age of Cynicism
It would be hard to dispute that we are living in an age of cynicism. Distrust is all around – especially when the subject is health. Thus, it should not be a surprise that consensus about diagnosing obesity turns out to be quite a challenge.
And yet, we are surprised that a global consensus on the distinction between present illness and the risk of future illness in obesity has met with such a skeptical or perhaps even cynical response. We are, of course, talking about the report of Lancet Commission on Clinical Obesity.
Starting from a Place of Agreement
From the perspective of Robert Kushner, someone deeply respected in obesity care, this should not be hard. He writes that the commission has really only three basic messages:
1. It’s time to move beyond BMI for clinical assessment.
2. It’s time to better define the disease of obesity.
3. Clinicians should target and tailor treatment according to health status.
So as hard as consensus across many different countries can be, it is remarkable that 58 experts from all over the world, as well as 75 medical organizations, all endorsed this work. Even some of the folks finding fault with the commission report seem to agree on these principles. In a very skeptical post on LinkedIn, Arya Sharma writes that “there is really nothing new in this report.”
Bones of Contention
But clearly, Sharma is not happy with the Lancet report. He calls it “disingenuous and misleading” to suggest that the report offers something new. That leaves us scratching our heads. If the report is not terribly different from prior work he has done, but it has a broad embrace from global experts and organizations, is that a bad thing?
EASO has its own framework for defining obesity, which it clearly prefers. The organization does not like drawing a distinction between people living with excess adiposity but without active disease (preclinical obesity) and people with excess adiposity who have the active disease. It will “delay crucial early interventions,” they write. The Obesity Medicine Association raises similar concerns.
Managing Risk for Future Illness
Clearly, consensus about diagnosing obesity is not an easy thing to build. Everyone has a pride of authorship for their own frameworks. And people have really mixed feelings about relying on BMI. It is easy, but flawed. In Medscape, Francesco Rubino, who led the Lancet Commission, is adamant that “the Commission did not recommend excluding people with preclinical obesity from coverage of weight management treatments.” Rather, the recommendation is to tailor therapy to the needs and preferences of individual patients.
Honestly, this does not seem radical to us. But admittedly, more work will be needed to define how best to do that. Mistrust and talking past respected colleagues will get in the way. Overcoming it will require an effort.
Click here for the Lancet Commission report, here for the EASO response, here for the OMA response, and here for more of our perspective on it. For reporting from Medscape on differing views about it, click here. If you would like some food for thought about alternatives to cynicism and mistrust, click here.
Cynic Philosopher with His Dog, painting by Nicolas Gosse and Auguste Vinchon / Wikimedia Commons
Subscribe by email to follow the accumulating evidence and observations that shape our view of health, obesity, and policy.
February 15, 2025
February 16, 2025 at 8:27 am, Anthony Fabricatore said:
Like you, I struggle to understand the backlash to this report. The guidance on diagnosing obesity seems very much aligned to the 2016 AACE Clinical Practice Guidelines, which essentially said: 1) use additional anthropometrics to corroborate the BMI; 2) the diagnosis requires a clinical assessment to determine if/how the excess adiposity is affecting health; and 3) Stage 0 obesity (later recalibrated to be called Stage 1), i.e., the presence of excess adiposity that has not (yet) manifested in complications, requires a different level of intervention than more severe disease.
While the concepts in the Lancet D&E Commission report may not be novel, the broad consensus on the concepts IS. Can you imagine what the backlash would have been if the Commissioners dropped something that no one had seen before? Or, worse, if they concluded that the status quo was the best possible status? (For the record, I acknowledge that there is a lot of ground between those two alternative scenarios and that the avoidance of backlash should not be the goal of a scientific consensus, but it is a fun thought experiment!)
Personally, I look at this report not as the last word but as a new starting point for thinking about obesity and how best to treat those affected. I think the Commissioners, in so many words, recommended that we see it as such.
Kudos to the Commissioners for moving us toward a better conceptualization of obesity. It is not perfect, but I ain’t mad at it. I’ll be focusing my scientific indignation and my rage about new developments in the world elsewhere! 😉
February 16, 2025 at 9:01 am, David Brown said:
Science is all about certainty. https://pmc.ncbi.nlm.nih.gov/articles/PMC2719747/
The World’s leading obesity experts do not know for certain what caused the dramatic increase in obesity. However, AI (artificial intelligence) can help clarify matters. When I did a ‘prostanoid overproduction insulin resistance’ web search, the AI Overview said, “Prostanoid overproduction can contribute to insulin resistance by impairing the body’s ability to effectively utilize insulin, primarily through inflammatory pathways activated by excessive prostaglandin production, leading to decreased glucose uptake in muscle and fat cells, which is a key characteristic of insulin resistance; essentially, too many prostaglandins can disrupt the normal insulin signaling cascade, making cells less responsive to insulin.”
Norwegian animal science researchers explain what causes prostanoid overproduction. https://pmc.ncbi.nlm.nih.gov/articles/PMC2875212/