Posts Tagged ‘body composition’

Much of the world seems stuck on chasing ever higher numbers for weight loss. But clearly we need better targets for innovation in obesity and metabolic health. At the recent BIO Investment & Growth Summit, Immunis CEO Hans Keirstead came to tell us the answer lies in the health of our muscles. He has a […]

This has been a long time coming and the path to get here has been tortured. Nature Medicine published new results of a rigorous phase two study with bimagrumab and semaglutide for obesity. The results are striking because the combination of these two drugs produces improvements in body composition we have never seen before in […]

While all eyes in obesity focused on the launch of a daily oral tablet for ongoing treatment, Arrowhead Pharmaceuticals brought us a little surprise yesterday. They presented early data from phase one studies of two gene silencing therapies for obesity. Though these data are quite preliminary, they offer a signal of great promise for a […]

If you want a younger, healthier brain, exercise that increases your muscle mass can help, says Gretchen Reynolds in the Washington Post: “More muscle mass was linked to younger brains in new research, suggesting resistance training can support long-term brain health.” She goes on to say: “If you need another reason to visit the gym […]

After the strong and subjective opinions we keep hearing about the uselessness of BMI, it is refreshing to see a careful analysis of objective data. A new study in Annals of Family Medicine suggests measuring percent body fat through bioimpedance is superior for predicting mortality linked to excess adiposity. Bioimpedance is the method seca and […]

Retatrutide is that impressively potent obesity medicine that teased us with remarkable weight loss outcomes back in 2023. As we wait for pivotal phase three data (now due later this year), we wonder about the risk for muscle loss with a drug that has the potency of retatrutide. A new paper in Lancet Diabetes & […]

Regeneron announced tantalizing results for the combination of trevogrumab with semaglutide for losing fat while preserving muscle. With the combination of these two drugs, it appears that individuals might lose more fat mass and less muscle mass than with semaglutide alone. In short, the promise is for a better quality of weight loss, leaving people […]

Amid a great deal of excitement about the value of GLP-1 medicines like semaglutide and tirzepatide for obesity, there is also a buzz of concern about muscle loss. Is it a reason to think twice about these new treatments? Or is it merely a reason for caution? Not Unique to GLP-1s Carla Prado, Stuart Phillips, […]

We’ve been hearing quite a lot about this on many levels. For years now, obesity thought leaders and even the public have had an increasingly sour relationship with BMI. It’s been misused, abused, detested, and even accused of racism. Yes, the love is gone. On Friday, the European Association for the Study of Obesity (EASO) […]

Obesity care is suffering from a blinding distraction – BMI and weight loss. It’s not hard to find critiques of this. The American Medical Association recently cautioned physicians against the misuse of BMI as a surrogate for health and obesity. PLOS One has a new paper telling us BMI may not necessarily increase mortality independently […]