Posts Tagged ‘fatty liver disease’

Sleeve vs Bypass: Effect on Liver Fat

November 30, 2021 — Following closely on a landmark study of bariatric surgery and liver fat, today we have a new RCT comparing the effects of gastric sleeve and gastric bypass. In short, these two procedures work equally well. After one year, patients with both procedures had about a 20 percent reduction in liver fat. The other endpoint was […]

Separate Hepatic Steatosis from Obesity? Not So Fast

November 11, 2020 — Nonalcoholic fatty liver disease. That’s the stigma-laden medical terminology for a condition also known as hepatic steatosis. This is a chronic disease that most often goes undetected, until it progresses to the inflamed state of hepatitis. But then it gets serious. The inflammation progresses to fibrosis. Liver failure or liver cancer can be the end […]

Semaglutide Hits a Milestone in NASH

May 7, 2020 — Nonalcoholic steatohepatitis – NASH – is a more severe form of fatty liver disease that can lead to cirrhosis and liver cancer. Like other complications of obesity, people can develop NASH even if their BMI does not fall into the range of obesity. Just like obesity, the prevalence of NASH is growing and the treatment […]

A Steep Price to Pay for Untreated NASH

January 11, 2020 — A new study in the January issue of Diabetes Care makes one thing very clear. We pay a steep price for untreated NASH – nonalcoholic steatohepatitis. This is a disease that starts with fat tissue building up in the liver. Then inflammation develops. After that, it can progress to liver damage and failure, ultimately requiring […]

Tony Villiotti: Hard Learned Lessons About NASH

October 3, 2019 — I come from a large Italian family where eating, and lots of it, was a priority. In college, I was very active and my weight was under control. Once I graduated, and especially after marriage and kids, my weight skyrocketed and I was clearly developing obesity. My love of eating and my weight led to […]

A Role For Gut Bacteria in Fatty Liver Disease?

September 23, 2019 — A new study in Cell Metabolism tells us that gut bacteria might play a role in the development of fatty liver disease. Jing Yuan and colleagues found that a strain of Klebsiella can cause fatty liver disease in mice. In addition, they found a correlation between the presence of these bacteria in humans and fatty […]

Does Shortness Bring a Risk for Type 2 Diabetes?

September 11, 2019 — A new study in Diabetologia tells us that shortness may heighten a person’s risk for type 2 diabetes. Over seven years, researchers observed a higher risk for type 2 diabetes among shorter people in a cohort of 2,500 individuals. Age, lifestyle, education, and waist circumference didn’t explain it. Even after accounting for those factors, the […]

Intercept Presents Encouraging NASH Results

April 12, 2019 — It’s been a long road for Intercept Pharmaceuticals to develop an important advance for treating NASH (non-alcoholic steatohepatitis). Five years ago this little startup company shocked the world when a monitoring board stopped a placebo-controlled study because their drug (obeticholic acid or OCA) had worked so well. A final round of 64 liver biopsies were […]

Cutting Sugar Clears Up Liver Disease in Children?

January 25, 2019 — JAMA grabbed some headlines this week on a popular subject – cutting sugar consumption for kids. Fatty liver disease is a serious problem and the headlines point to a simple solution. “To fight fatty liver, avoid sugary foods and drinks,” said the New York Times. How did researchers prove that? All it took was a randomized […]

Fatty Liver in the Womb

March 9, 2018 — Is the die already cast for obesity when an infant is born? Maybe not entirely, but in new research this week, we have fresh insight into physiology that can stack the odds before birth. Sobha Puppala and colleagues found that maternal obesity during pregnancy can lead to fatty liver in a fetus. So at birth, […]