December 12, 2025 — “I am over the moon about this,” said Harvard professor Caroline Apovian to us. She was talking about the outstanding topline results with retatrutide reported by Lilly from a phase three study. This is the so-called triple-G agonist that first stunned the world with its phase two results two years ago. In the results yesterday, […]
December 8, 2025 — browser does not support iframeWe write a great deal here about obesity care. That phrase reflects the fact that obesity is a complex chronic disease typically requiring lifelong care. Not just a simple weight loss intervention. But most of the world is not thinking in those terms. And the research symposium last week at NIH […]
December 5, 2025 — The attention that goes daily to the subject of preserving muscle and its importance is off the chart. Just this week a call to action about muscle loss in diabetes and a new systematic review on the effects of resistance exercise on cognitive function are demanding our attention. It is clear that preserving muscle as […]
November 20, 2025 — “Big food is taking over,” says Barry Popkin, adding an exclamation point in the New York Times to a growing roar of condemnation for ultra-processed foods. The occasion for this is the publication of three new papers – plus an editorial – all at once in The Lancet this week. Popkin was an author on […]
November 4, 2025 — It was remarkable and much needed. On the pre-convention day for ObesityWeek in Atlanta, ADA, OAC, and TOS began work to collaborate on models for obesity care that will begin to deliver on a scale that matches the urgency and scope of unmet medical need. TOS Vice-President Jonathan Purnell described the urgency of this to […]
October 24, 2025 — A new study in Lancet tells us that we need a fundamental reframing of the medical benefits semaglutide can bring to a growing number of people around the world. In the simplest terms, researchers have found that the heart benefits of semaglutide actually have relatively little to do with weight loss. Professor John Deanfield was […]
September 21, 2025 — Julia Belluz and Kevin Hall have some Food Intelligence to offer us this week and their book of this title will be shipping on Tuesday. No, this is not a paid endorsement. It is, though, an earnest recommendation to learn from two of the most thoughtful people we know on the subject of food, health, […]
September 16, 2025 — Today in Nature Medicine, compelling new research tells that long-term outcomes with metabolic surgery are superior to the outcomes with GLP-1 agonists in persons with diabetes and obesity. These are impressive and important results. But we have to wonder if anyone is really listening. The enthusiasm for advanced obesity medicines is so great that many […]
September 9, 2025 — The progress we have witnessed in 25 years of working on obesity care has been nothing short of remarkable. Especially in the last four years with the introduction of advanced new obesity medicines. But let’s step back from the minutia of research, clinical care, and policy, to look at the big challenges that remain. When […]
August 27, 2025 — It’s entertaining in a perverse way. Cluelessness about the potential of orforglipron is impossible to miss in the news about Lilly’s new oral GLP-1 medicine for obesity this month. The company announced topline results from the first of two pivotal studies for this medicine on August 7 and investors decided the drug was a dud. […]
