July 31, 2024 — A fascinating new study in Annals of Internal Medicine asks an important question. When people receive semaglutide for type 2 diabetes, are they less likely to smoke? This is not such a random question. In fact, clinicians are reporting striking reductions in addictive behaviors by people receiving it for obesity. So William Wang and colleagues […]
July 27, 2024 — It’s been a rough month for investors in Lilly and Novo Nordisk – largely because of the prospects for rising competition to their wildly successful obesity medicines. Accelerating VK2735 This week, Viking Therapeutics announced they are accelerating development of injectable form of VK2735, a dual agonist that works on both GLP-1 and GIP receptors. This […]
May 3, 2024 — Reports of first quarter business results from Novo Nordisk and Eli Lilly this week leave no room for doubt. The utilization of obesity treatment is growing at a rate that has caught both of these companies by surprise. Wegovy sales more than doubled in the first quarter of 2024. On top of that, new prescriptions […]
March 16, 2024 — Firsts are worth celebrating. In this case, the cause for celebration is especially great. MASH or metabolic steatohepatitis is a disease that is growing dramatically more common and more harmful to the health of the population. Late this week, FDA approved resmetirom to be the first ever treatment for MASH with fibrosis. Note that the […]
February 27, 2024 — Yet another GLP-1 agonist in development for obesity – survodutide – showed promising results yesterday from a phase 2 clinical trial in MASH. In case you missed the notice, MASH is the new acronym for what we used to label as NASH. We also note that MASLD has replaced NAFLD in the nomenclature alphabet soup […]
January 10, 2024 — Some things never change. Half a century ago, editors of the Lancet proclaimed that “most obesity could, with care, be prevented.” Drugs have “limited usefulness” for treating obesity, they explained, and so, “we need to be more vigilant about preventing obesity throughout childhood.” After 50 years of relying on this advice, obesity prevalence has tripled. […]
December 29, 2023 — Right now, the public and policy makers are grappling with innovations in obesity that we already have. But scientists are peering over the horizon. They are dreaming – asking important questions about long-term success in overcoming obesity. Stat News describes this as a “quest to eradicate obesity” – a frame for this work that misses […]
December 15, 2023 — It’s long been overdue. For as long as we can remember, one presumption has been dominant. The real cure for obesity is (supposed to be) a change in lifestyle. It is the “foundation of obesity treatment” says just about everyone, even today. But the sand underneath that foundation is shifting. So the time has come […]
November 9, 2023 — In an era of tremendous change for obesity care, this is certainly a huge milestone. FDA approved tirzepatide for obesity treatment yesterday and put Lilly in the position to offer serious competition to Novo Nordisk. But the question that matters most to us is simple. How will this competition help people seeking to cope with […]
October 12, 2023 — We’re packing for Dallas and looking forward to soaking up as much innovation, science, and policy as we can when all the world’s top experts gather to share their best thinking at ObesityWeek 2023. There’s a lot to absorb in just four days, so advance planning is the key. Here are ten sparks from the […]
