August 9, 2019 — New data from Rhythm Pharmaceuticals this week tells us that a new, highly targeted obesity therapy may become available soon. The data come from two phase 3 studies of setmelanotide in rare cases genetic obesity. With these positive results in hand, Rhythm expects to file for FDA approval in late 2019 or early 2020. Thus, […]
July 5, 2017 — More than 20 years ago, discovery of the ob (obesity) gene and the protein that it encodes – leptin – was a breakthrough for obesity science. Mice that lack the gene develop extreme obesity. And giving them the protein reverses it. Some people misleadingly dubbed it a satiety hormone. In Cell Metabolism, a new commentary by Jeffrey […]
October 13, 2015 — The notion of endorphins kicking in to produce a runner’s high at the end of a good run is an enduring legend taken as an absolute truth by most runners. The catch is that no real evidence exists to prove that’s how it works. But in the last week we’ve had a flurry of animal research suggesting […]
August 31, 2015 — In case you haven’t noticed, most people who try to lose significant amounts of weight through sheer force of will inevitably gain it back. Weight loss fails not because of a failure of willpower. It fails because your brain works so well to regulate your weight and protect you from the existential threat of weight […]
