Posts Tagged ‘liver disease’

How BMI Can Miss Unhealthy Fat in the Liver

May 18, 2022 — One of the important complications of obesity is NAFLD – non-alcoholic fatty liver disease. Quite simply, this is a condition where unhealthy fat accumulates in the liver. It leads to inflammation and fibrosis, progressing to cirrhosis, liver cancer, or liver failure in severe cases. Often, it goes undetected until these more severe problems emerge. Because […]

Sleeve vs Bypass: Effect on Liver Fat

November 30, 2021 — Following closely on a landmark study of bariatric surgery and liver fat, today we have a new RCT comparing the effects of gastric sleeve and gastric bypass. In short, these two procedures work equally well. After one year, patients with both procedures had about a 20 percent reduction in liver fat. The other endpoint was […]

Cutting NASH Harms by 88% with Bariatric Surgery

November 12, 2021 — NASH (non-alcoholic steatohepatitis) is one of the most serious complications of untreated obesity. It’s very hard to treat. It can lead to liver failure, liver cancer, and death. So when a careful study of bariatric surgery shows an an 88 percent reduction in the risk of NASH progressing, this is big news. JAMA published this […]

Separate Hepatic Steatosis from Obesity? Not So Fast

November 11, 2020 — Nonalcoholic fatty liver disease. That’s the stigma-laden medical terminology for a condition also known as hepatic steatosis. This is a chronic disease that most often goes undetected, until it progresses to the inflamed state of hepatitis. But then it gets serious. The inflammation progresses to fibrosis. Liver failure or liver cancer can be the end […]

The Tortured Pathway for a New NASH Treatment

June 30, 2020 — It’s tough getting good information these days. Good, factual information. Everybody wants to spin it. That’s undeniable in public policy. But it also seems to be true in drug development. Yesterday, the FDA definitively rejected an application from Intercept Pharmaceuticals for a new drug to treat NASH – nonalcoholic steatohepatitis. The company was shocked. Its […]

Semaglutide Hits a Milestone in NASH

May 7, 2020 — Nonalcoholic steatohepatitis – NASH – is a more severe form of fatty liver disease that can lead to cirrhosis and liver cancer. Like other complications of obesity, people can develop NASH even if their BMI does not fall into the range of obesity. Just like obesity, the prevalence of NASH is growing and the treatment […]

Tony Villiotti: Hard Learned Lessons About NASH

October 3, 2019 — I come from a large Italian family where eating, and lots of it, was a priority. In college, I was very active and my weight was under control. Once I graduated, and especially after marriage and kids, my weight skyrocketed and I was clearly developing obesity. My love of eating and my weight led to […]

Obesity and Diabetes Bringing More Liver Disease

August 19, 2019 — The nature of liver disease is shifting in the U.S. Over the last three decades, hepatitis C has dropped by nearly half. But over that same time, we’ve seen more liver disease due to obesity and diabetes. In fact, NAFLD (non-alcoholic fatty liver disease) has grown in almost perfect synchrony with obesity and type 2 […]

NASH: The Invisible Complication of Untreated Obesity

November 28, 2017 — When most people think about obesity, the only complication they think of is type 2 diabetes. Quite a few people (but not a majority) think of heart disease. But few people think about liver disease. Unfortunately, Nonalcoholic steatohepatitis (NASH) can be one of the most serious complications a person with obesity will face. NASH is […]

What’s This about Coffee Saving Us from Obesity?

November 17, 2014 — Headlines lately have been suggesting the possibility of coffee saving us from obesity. Here’s a sampling: Coffee May Help Combat Obesity New Research Touts Benefits of Coffee in Combating Diabetes, Obesity Coffee Chemical Could Offset Diseases Related to Obesity Coffee May Help You Shed Weight! Drinking Coffee May Soon Become the Quickest Way to Lose […]