Posts Tagged ‘NAFLD’

Looking for “Culprits” in Fast and Take-Out Food

June 18, 2022 — Two new studies in AJCN provide observations on the relationship between health outcomes and fast food, take-out, café, or home-cooked meals. These studies find an association of worse outcomes with fast food and take out. But the real question is, why? What are the causal relationships behind these observations? In an editorial, Barry Popkin suggests […]

How BMI Can Miss Unhealthy Fat in the Liver

May 18, 2022 — One of the important complications of obesity is NAFLD – non-alcoholic fatty liver disease. Quite simply, this is a condition where unhealthy fat accumulates in the liver. It leads to inflammation and fibrosis, progressing to cirrhosis, liver cancer, or liver failure in severe cases. Often, it goes undetected until these more severe problems emerge. Because […]

Sleeve vs Bypass: Effect on Liver Fat

November 30, 2021 — Following closely on a landmark study of bariatric surgery and liver fat, today we have a new RCT comparing the effects of gastric sleeve and gastric bypass. In short, these two procedures work equally well. After one year, patients with both procedures had about a 20 percent reduction in liver fat. The other endpoint was […]

Bariatric Surgery and the Risk of Cancer

March 29, 2021 — Cancer is one of the risks of obesity that many people do not appreciate. Diabetes and heart disease have links to obesity that many people understand. But cancer as a complication of obesity has not made the charts. Nonetheless, obesity clearly raises the risks of 13 different kinds of cancer. A new study in Gastroenterology […]

Progress on NASH Treatments, But No Home Run Yet

November 22, 2020 — This month has brought considerable progress on NASH treatments. Yet it’s hard to know when we will have real progress in medical care for this silent epidemic. Getting FDA to yes on new treatments seems to be a challenge. Nonetheless, we have news of two new studies that suggest promise for new NASH treatments. One […]

Separate Hepatic Steatosis from Obesity? Not So Fast

November 11, 2020 — Nonalcoholic fatty liver disease. That’s the stigma-laden medical terminology for a condition also known as hepatic steatosis. This is a chronic disease that most often goes undetected, until it progresses to the inflamed state of hepatitis. But then it gets serious. The inflammation progresses to fibrosis. Liver failure or liver cancer can be the end […]

Semaglutide Hits a Milestone in NASH

May 7, 2020 — Nonalcoholic steatohepatitis – NASH – is a more severe form of fatty liver disease that can lead to cirrhosis and liver cancer. Like other complications of obesity, people can develop NASH even if their BMI does not fall into the range of obesity. Just like obesity, the prevalence of NASH is growing and the treatment […]

A Steep Price to Pay for Untreated NASH

January 11, 2020 — A new study in the January issue of Diabetes Care makes one thing very clear. We pay a steep price for untreated NASH – nonalcoholic steatohepatitis. This is a disease that starts with fat tissue building up in the liver. Then inflammation develops. After that, it can progress to liver damage and failure, ultimately requiring […]

Obesity and Diabetes Bringing More Liver Disease

August 19, 2019 — The nature of liver disease is shifting in the U.S. Over the last three decades, hepatitis C has dropped by nearly half. But over that same time, we’ve seen more liver disease due to obesity and diabetes. In fact, NAFLD (non-alcoholic fatty liver disease) has grown in almost perfect synchrony with obesity and type 2 […]

Intercept Presents Encouraging NASH Results

April 12, 2019 — It’s been a long road for Intercept Pharmaceuticals to develop an important advance for treating NASH (non-alcoholic steatohepatitis). Five years ago this little startup company shocked the world when a monitoring board stopped a placebo-controlled study because their drug (obeticholic acid or OCA) had worked so well. A final round of 64 liver biopsies were […]