Posts Tagged ‘pharmaceutical research’

A Little More Detail on Tirzepatide in MASH at EASL

June 6, 2024 — On the opening day of the EASL Congress in Milan, we got a peek at more details on the results of the phase 2 study of tirzepatide in MASH (metabolic dysfunction associated steatohepatitis). The study, called SYNERGY-NASH, will be the subject of a late-breaking presentation on Saturday at the meeting. But the release of the […]

Will We Always Have to “Keep Taking” Obesity Medicines?

April 26, 2024 — Perhaps the most persistent fault that people find with new obesity medicines is the need to keep taking them forever. “Nobody is ready ” for that, says Business Insider. “Patients hate forever drugs,” says the New York Times. And they have a point. Obesity medicine doctors are quick to say “suck it up.” That’s just […]

From Weight Loss to Obesity to Cardiorenal Metabolic Health

March 22, 2024 — A profound shift in the understanding of medicines that help with excessive or abnormal fat is underway. A few years ago, everybody thought of these in only one frame of reference – weight loss drugs. But that is changing now. Discourse about them is moving from weight loss to obesity treatment and even further, to […]

FDA Approves Resmetirom: First Ever for MASH with Fibrosis

March 16, 2024 — Firsts are worth celebrating. In this case, the cause for celebration is especially great. MASH or metabolic steatohepatitis is a disease that is growing dramatically more common and more harmful to the health of the population. Late this week, FDA approved resmetirom to be the first ever treatment for MASH with fibrosis. Note that the […]

Gee Whizzy New Drugs for Weight Loss or Obesity

March 13, 2024 — The drug development pipeline is filling up with new new drugs for weight loss or obesity. On Thursday, Novo Nordisk caused the hearts of investors to flutter when it presented topline results on an oral medicine that might be more effective than semaglutide. The value of the company’s stock jumped by 13%. Just a week […]

Progress Reported in MASH with Survodutide

February 27, 2024 — Yet another GLP-1 agonist in development for obesity – survodutide – showed promising results yesterday from a phase 2 clinical trial in MASH. In case you missed the notice, MASH is the new acronym for what we used to label as NASH. We also note that MASLD has replaced NAFLD in the nomenclature alphabet soup […]

From Lukewarm to Two Billion Dollars for Bimagrumab

July 15, 2023 — Four years ago, bimagrumab was a castoff from Novartis. That company had originally developed this monoclonal antibody for treating a rare muscle disease. But it failed spectacularly with disappointing results from a phase 2b study in 2016. That was a big disappointment, so it’s little wonder that Novartis walked away. Three years later, a glimmer […]

Scratching the Surface with New Obesity Meds

May 9, 2023 — With all the sensational reporting about semaglutide and tirzepatide for obesity – often with the emphasis on weight loss – you might think a revolution is underway. Yes, it is coming. But the truth is that it hasn’t even started yet. At present, for a number of reasons, we are barely scratching the surface of […]

Suddenly Bullish on Anti-Obesity Medicines?

January 12, 2022 — It’s been a long haul. But suddenly, we’re seeing a lot of optimism about anti-obesity medicines. Skeptics are yielding to stubborn facts about the impact of obesity on health. They are also yielding to good clinical data about the benefits of sound obesity care. So, too, are they seeing that newer generations of anti-obesity medicines […]

Tirzepatide Shows Good Weight Outcomes in Diabetes

October 20, 2021 — Day by day, the prospects for treating obesity are getting better. Late on Monday, detailed results from the longest study yet of tirzepatide came out in Lancet. This was a study using this new drug in people with type 2 diabetes, but the average BMI of these patients was 33. None of them had a […]