Posts Tagged ‘research’

Innovation and Competition in Obesity Gains Momentum

August 9, 2021 — Could it be that innovation and competition for better obesity care will overtake the health problem of obesity? We see several signs pointing to this. A decade ago, it was tough to get FDA to take obesity innovation seriously. So big pharma research was running from the challenge. Sanofi had invested heavily in developing rimonabant […]

Changing Our Minds About Nutrition and Obesity

August 2, 2021 — We see a lot of stubborn opinions about nutrition and obesity research. People dig intellectual trenches and defend their positions about sugar, salt, and fat. Suppositions turn into convictions. Data becomes a tool for proving a point. Or inconvenient data leads a professor say we have to stomp it out. It’s depressing, really, if we […]

Genetic Sequences to Protect from Obesity

July 6, 2021 — Cambridge Professor Sadaf Farooqi calls it a tour de force of genetics. Researchers from Regeneron and nine international research centers sequenced genetic exomes in 645,626 persons. With this painstaking research, they’ve found genetic sequences that protect some people from obesity. These sequences hard wire a person for leanness. In a world that prizes a lean […]

Normal Weight Obesity: Unhealthy at Any Size

May 19, 2021 — It’s tough to get people to let go of weight and body size as the defining feature of obesity. But indeed, weight does not define obesity. Nor does BMI. What defines obesity is abnormal or excess fat (adipose) tissue that harms health. Most often, this occurs when someone’s weight is high. Not always, though. In […]

Semaglutide in JAMA Again: Maintaining a Benefit

March 24, 2021 — If you had any doubt about prior reports that semaglutide is likely to be a “game changer” for obesity care, perhaps you should look at JAMA today. Just one month after another paper in JAMA, semaglutide is back in the journal. This time, it is a 68-week study that shows the value of maintaining therapy […]

HIIT Takes a Hit in an RCT for Certain Heart Patients

February 10, 2021 — High intensity interval training (HIIT) is hot right now. It mixes short periods of very intense exercise with less intense recovery. Even before the pandemic, interest in HIIT had grown dramatically. Then it spiked when pandemic lockdowns began. But a new RCT published yesterday in JAMA suggests that it might not be a panacea for […]

Data Thugs, Pajamas, and Ultra-Processed Food

January 30, 2021 — Nevermind. As far as we can tell, that’s the bottom line on a convoluted story about data thugs, pajamas, and a provocative study of ultra-processed food. It starts with the study by Kevin Hall et al that found ultra-processed food can cause people to eat more and gain weight. All by itself, that finding was […]

Bimagrumab: Hesitancy and Promise in Obesity Care

January 26, 2021 — Innovation in obesity care has come a long way. Back in 2010, Sanofi was smarting from the spectacular failure of rimonabant and big pharma was closing down research programs in obesity. But Novo Nordisk forged ahead with an ambitious program and now has a successful portfolio in obesity care to show for it. Nonetheless, we […]

Retraction: A Difficult Measure of Integrity

January 13, 2021 — Mistakes can be hard to admit. We see vivid examples. Someone makes a grievous error and yet claims their actions were “totally appropriate.” Even though they’re obviously wrong. Likewise, when a journal makes a mistake by publishing a flawed paper, a retraction can be quite difficult. But that’s precisely what Scientific Reports did yesterday. The […]

Moderna Vaccine Works Well, Even with Severe Obesity

December 16, 2020 — Right now, if you search Google for COVID vaccine obesity, the top result will be a story from Nature that says the vaccine might not work well for people with obesity. But the truth is quite different. Because yesterday, FDA released data on the Moderna vaccine, and it works quite well, even in people with […]