November 26, 2025 — It seems like some good news is overdue for Novo Nordisk. So the topline report of a phase two study with amycretin that looks like a plausible win is especially welcome. The results at hand come from a 36-week placebo controlled study with a wide range of oral and injection doses in persons with type […]
November 21, 2025 — The sprint to the finish for orforglipron is picking up pace with a pivotal trial in obesity and diabetes published yesterday in The Lancet. Things are looking good for this relatively simple GLP-1 agonist in a tablet. The presentation of these results from ATTAIN-2 were a highlight of ObesityWeek earlier this month, but having this […]
September 19, 2025 — This week has been a flood of news from the EASD meeting in Vienna. Yesterday, the big news was an impressive win for kids 10-17 with type 2 diabetes in a study of tirzepatide. Researchers presented the SURPASS-PEDS trial and simultaneously published it in Lancet. At the end of the 30-week trial, tirzepatide in two […]
August 12, 2025 — Yesterday the Canadian Medical Association Journal and Obesity Canada published new clinical guidance for obesity medicines – a leap forward that reflects great clinical progress in pharmacotherapy. This is the second revision to the chapter on pharmacotherapy since the Canadian guideline for adult obesity care was first published in 2020. The chapter was also updated […]
April 18, 2025 — The news in obesity research these days is so full of headlines about a multitude of new medicines in development that it is easy to lose count. All too often, these are early stage or even pre-clinical notions of a potential treatment. So yesterday, it was good news indeed to hear that a once-daily oral […]
December 7, 2024 — The concept of turning food into medicine mildly repels us. But telling us chocolate is medicine simply goes over the line. Yet here comes a study in the BMJ, spinning off headlines about dark chocolate as a “bittersweet remedy for diabetes risk.” Milk chocolate? Nope. In fact, the authors of this observational study say milk […]
November 14, 2024 — In the New England Journal of Medicine yesterday, detailed results of a three-year study showed that tirzepatide was 99% effective in preventing diabetes in people with prediabetes and obesity. This was a placebo-controlled trial. Every person in the study, whether they received tirzepatide or not, received regular lifestyle counseling. Compared to the control group getting […]
October 10, 2024 — After a recent cascade of diverse studies yielding seemingly different answers about time-restricted eating, FNCE this week provided an excellent opportunity to gain perspective from researchers who are serious about this subject. Krista Varady, Shuhao Lin, and Vicky Pavlou brought a much needed focus on the science behind this pop nutrition phenomenon. A Helpful Alternative […]
August 30, 2024 — Scientists have a pretty good handle on how to predict a person’s risk of diabetes and how to diagnose it. The gold standard is a glucose tolerance test. How does your body handle glucose? But diabetes is just one dimension of dietary disease risk and nutrition scientists are hungry for a better way to predict […]
August 28, 2024 — Type 2 diabetes prevalence is up and the Lancet Regional Health has a simple way to reduce it. Daniel Windred and colleagues write: “Advising people to turn off their lights at night, or use lights that reduce the circadian impact (dim and “warm” light), is a simple, cost-effective, and easily-implementable recommendation that may promote cardiometabolic […]
