December 12, 2025 — “I am over the moon about this,” said Harvard professor Caroline Apovian to us. She was talking about the outstanding topline results with retatrutide reported by Lilly from a phase three study. This is the so-called triple-G agonist that first stunned the world with its phase two results two years ago. In the results yesterday, […]
December 5, 2025 — The attention that goes daily to the subject of preserving muscle and its importance is off the chart. Just this week a call to action about muscle loss in diabetes and a new systematic review on the effects of resistance exercise on cognitive function are demanding our attention. It is clear that preserving muscle as […]
November 2, 2025 — The headlines won’t stop. “Obesity rates are falling and it’s almost certainly because of Ozempic,” says the Futurism banner. Vox tells us “the Ozempic effect is finally showing up in obesity data.” So can it be true that use of GLP-1s is lowering obesity prevalence? The short answer is no. Not now. Probably not ever. […]
October 24, 2025 — A new study in Lancet tells us that we need a fundamental reframing of the medical benefits semaglutide can bring to a growing number of people around the world. In the simplest terms, researchers have found that the heart benefits of semaglutide actually have relatively little to do with weight loss. Professor John Deanfield was […]
October 8, 2025 — As an article of faith, many people, even some who should know better, dispense advice that sweeteners are bad for metabolic health and weight management. They rely on observational evidence and theories about how they might have subtle effects to undermine health. But no direct evidence. Now, in Nature Metabolism comes a randomized controlled study to […]
September 27, 2025 — Bimagrumab continues to be a enigma. We see flickering signs of good news – and then, inexplicably, it goes dark. The pattern repeated itself this week when news emerged that Lilly pulled the plug on a phase two study with bimagrumab and tirzepatide in persons with obesity and diabetes before it even enrolled a single […]
September 25, 2025 — This one definitely sounded too good to be true from the start. A little bit of apple cider vinegar daily for young persons with obesity supposedly produced lower body weight, BMI, body fat ratio, blood sugar, triglycerides, and cholesterol. No side effects. However, this stunning piece of research on apple cider vinegar in obesity was […]
September 9, 2025 — The progress we have witnessed in 25 years of working on obesity care has been nothing short of remarkable. Especially in the last four years with the introduction of advanced new obesity medicines. But let’s step back from the minutia of research, clinical care, and policy, to look at the big challenges that remain. When […]
August 21, 2025 — Yes, wearable tech for personal health and fitness monitoring is still with us, but it comes in waves. The first wave, with Fitbit, peaked sometime around 2017, judging from Google search interest. The second wave came with smartwatches. The Apple Watch launched in 2015 and interest in smartwatches peaked in 2020. Now the hot new […]
August 18, 2025 — We have a flourishing market for new obesity drugs. But that market has a problem. New drug developers are stumbling over what to target with their drugs. The old way of looking at goals for new drugs in this space was to aim for greater weight loss. More is better – right? In a new […]
