December 20, 2025 — News from Lilly about orforglipron this week points to what might be the next big development for GLP-1 medicines. The company announced topline results for a weight maintenance study of orforglipron and this first glimpse has us thinking that maintain might be the magic word in obesity care next year. The topline come from the […]
October 8, 2025 — As an article of faith, many people, even some who should know better, dispense advice that sweeteners are bad for metabolic health and weight management. They rely on observational evidence and theories about how they might have subtle effects to undermine health. But no direct evidence. Now, in Nature Metabolism comes a randomized controlled study to […]
February 6, 2024 — We learned recently that questions about the need for ongoing dosing with obesity medicines raise discomforting thoughts. After all, obesity is a chronic disease, so we can’t dispute the need for continued daily or weekly doses with obesity medicines. Or can we? Amgen seems to think we can. Monthly Dosing? Induction and Maintenance? With a […]
October 6, 2023 — At EASD this week, it was quite a showing for tirzepatide. Sold under the brand name Mounjaro, it’s already available for treating diabetes and it’s awaiting approval for treating obesity. Based on the research presented at EASD this week, semaglutide might be looking a little like old news. For tirzepatide, a total of 11 presentations […]
May 30, 2022 — It’s pretty easy to find advice to make small changes that stick if a person wants to lose weight – or keep from gaining weight. It certainly sounds authoritative when a PhD psychologist offers up small change theory as a winning strategy: “When you focus on just a couple of small changes at a time, […]
May 23, 2022 — As we explained yesterday, there’s quite a body of research on the food cues that surround us and keep prodding us to eat. Food marketing embeds itself deeply in our daily lives. We suspect it explains a lot about our obesogenic food environment. Yet changing that environment has proven to be quite a challenge. So […]
May 11, 2022 — Many people are not getting enough sleep and the trend is going in the wrong direction. This is a problem for youth and working adults alike. New data again reminds us that good sleep is an important tool for overcoming obesity. But the diet and exercise trope that dominates public discourse about obesity crowds out […]
February 10, 2022 — What is it about body weight and obesity that activates so many people in so many different ways? As people weigh the rituals of body weight, the reactions may be very different, but they are often just as intense as they are diverse. In the Washington Post today, Fortesa Latifi writes with intensity about telling […]
December 21, 2021 — If nothing else, we have learned in recent years that it is possible to rationalize anything. In the pandemic and in politics, we see people taking a set of facts and coming up with wildly different interpretations. Likewise in science, we have to think hard about how to make sense of new findings. With new […]
May 26, 2021 — It’s pretty clear that spending a lot of time sitting isn’t helpful. Heart and metabolic health takes a hit. Weight tends to accumulate. Also clear is the fact that people who succeed in losing and keeping weight off tend to spend less time sitting and watching TV. Now data from 4,305 individuals in WW tells […]
