November 19, 2024 — Fat cells don’t forget. That simple fact comes from new research published in Nature yesterday which explains a fundamental truth about obesity that eludes most people in their thinking about this condition. It is a chronic disease. Fat cells have an epigenetic memory for obesity they retain even when people lose a lot of weight. […]
May 12, 2024 — A pair of studies with semaglutide at ECO2024 in Venice goes straight to the heart of some core questions about advanced obesity medicines. Does everyone need the full, maximum dose to get good results? Will everyone have to keep taking that full dose to keep obesity under control? The answer to both questions is no. […]
January 30, 2024 — It created quite a stir last week when Epic Research published an analysis suggesting that weight regain in the real world does not look the same as a placebo-controlled trial. After all, regain is quite an important subject. Obesity is clearly a chronic disease, requiring chronic care. But lots of people try to avoid this […]
January 25, 2024 — One of the more annoying generalizations in obesity is the assertion that when people lose weight, everyone inevitably regains it all and perhaps even more. When said about metabolic surgery, it’s utterly false. But that doesn’t stop people from saying it – even people who pose as medical experts. More broadly in the medical management […]
December 13, 2023 — “The long run is a misleading guide to current affairs. In the long run we are all dead,“ wrote John Maynard Keynes. But Keynes was obviously not a doctor. So his words don’t hold much sway over people who have questions about obesity medicines with impressive short-term results. But for those people, a new study […]
October 6, 2023 — At EASD this week, it was quite a showing for tirzepatide. Sold under the brand name Mounjaro, it’s already available for treating diabetes and it’s awaiting approval for treating obesity. Based on the research presented at EASD this week, semaglutide might be looking a little like old news. For tirzepatide, a total of 11 presentations […]
June 15, 2021 — Bias makes us human. It can even help us thrive by recognizing patterns in our lives. But of course, bias is sneaky, reinforcing patterns that keep people down for no good reason. So it is with weight bias – which some people believe causes more harm than obesity itself. One of the ways that weight […]
December 13, 2017 — We have a new window into the thinking of primary care physicians (PCPs) about obesity. But the view is dismal. On the subject of obesity, physicians believe that that biology is not so important. Why do people with obesity tend to regain weight? Physicians say behavioral factors are more important than biology. Likewise, they rated […]
